Recent Referred Publications

154. Meng XJ. 2008. Hepatitis E virus: animal reservoirs and zoonosis. Veterinary Microbiology. (invited review, in press)

153. Meng XJ, D.S. Lindsay, and N. Sriranganathan. 2008. Wild Boars as Sources for Infectious Diseases in Livestock and Humans. Philosophical Transactions of the Royal Society B (Biological Sciences). (invited review, in press).

152. Meng XJ. 2008. Hepatitis E Virus. In: Dana Cole and Jan Vinje (eds), Fate and Transport of Zoonotic Bacterial, Viral, and Parasitic Pathogens during Swine Manure: Treatment, Storage, and Land Application. National Pork Board Publishing Press. (invited review, in press).

151. Gillespie J, N.M. Juhan, J. DiCristina, K.F. Key, S. Ramamoorthy, and X.J. Meng. 2008. A genetically-engineered chimeric vaccine against porcine circovirus type 2 (PCV2) is genetically stable in vitro and in vivo. Vaccine. In Press, 2008 Jun 6. [Epub ahead of print]

150. Meng XJ. 2008. Hepatitis E virus (hepevirus). Encyclopedia of Virology, 3rd edition. B.W.J. Mahy and M. van Regenmortel (eds). Elsvier/Academic Press. ISBN: 0-12-373935-7.

149. Billam P, F.W. Pierson, W. Li, T. LeRoith, R. Duncan, and X.J. Meng. 2008. Development and Validation of a Negative Strand-Specific RT-PCR Assay for Detection of a Chicken Strain of Hepatitis E Virus: Identification of Non-Liver Replication Sites. Journal of Clinical Microbiology. In Press, 2008 Jun 18. [Epub ahead of print]

148. Patterson AR, Johnson J, Ramamoorthy S, Meng XJ, Halbur PG, Opriessnig T. 2008. Comparison of three enzyme-linked immunosorbent assays to detect porcine circovirus type 2 (PCV2)-specific antibodies after vaccination or inoculation of pigs with distinct PCV1 or PCV2 isolates. Journal of Veterinary Diagnostic Investigation. In Press.

147. Opriessnig T, S. Ramamoorthy, D.. Madson, A. Patterson, N. Pal, S. Carman, X.J. Meng, P.G. Halbur. 2008. Differences in virulence among porcine circovirus type 2 isolates are unrelated to cluster type 2a or 2b and prior infection provides heterologous protection. Journal of General Virology. In Press.

146. Madson D.M., S. Ramamoorthy, C. Kuster, N. Pal, X.J. Meng, P.G. Halbur, T. Opriessnig. 2008. Characterization of shedding patterns of porcine circovirus type 2a and type 2b in experimentally inoculated mature boars. Journal of Veterinary Diagnostic Investigation. In Press (November issue).

145. Ramamorthy S., and X.J. Meng. 2008. Porcine Circovirus: A Minuscule yet Mammoth Paradox. Animal Health Research Reviews. In Press.

144. Opriessnig T., A. R. Patterson, D. Jones, N. M. Juhan, X. J. Meng, and P. G. Halbur. 2008. Susceptibility of three different mouse lines to porcine circovirus type 2 infection and lesions. Canadian Journal of Veterinary Research. In press.

143. Guo H., E.M. Zhou, Z.F. Sun, and X.J. Meng. 2008. Immunodominant epitopes mapped by synthetic peptides on the capsid protein of avian hepatitis E virus (avian HEV) are non-protective. Viral Immunology. In press.

142. N. Pal, Y.W. Huang, D.M. Madson, C. Kuster, X.J. Meng, P.G. Halbura, and T. Opriessnig. 2008. Development of a duplex real-time PCR assay for the simultaneous detection and quantification of porcine circovirus type 2 and an internal control on porcine semen samples. Journal of Virological Methods. In press.

141. Purkayastha A, C. Oswald, JD Eckart, M Czar, XJ Meng, J. Setubal, and B. Sobral. 2008. Bioinformatics resources for the study of viruses at the Virginia Bioinformatics Institute. In: R. Holland Cheng, and Tatsuo Miyamura (eds), Structure-Based Study of Viral Replication. ISBN 981-270-405-1. Chapter 10. World Scientific Publishing Company, Stockholm, Sweden. Published January 2008.

140. Feagins AR, T. Opriessnig, D.K. Guenette, P.G. Halbur, and X.J. Meng. 2008. Inactivation of infectious hepatitis E virus in commercial pig livers. International Journal of Food Microbiology. 123:32-37.

139. Meng XJ. 2008. Hepatitis E virus (hepevirus). Encyclopedia of Virology, 3rd edition. Elsvier/Academic Press. pp. ??.

138. Opriessnig T., Patterson AR, Elsener J, Meng XJ, Halbur PG. 2008. Influence of porcine circovirus type 2 (PCV2) maternal antibodies on efficacy of PCV2 vaccination to protect pigs from experimental infection with PCV2. Clinical and Vaccine Immunology. Dec 19; [Epub ahead of print].

137. Matanin M, Y.W. Huang, X.J. Meng, and C. Zhang. 2008. Purification of the major envelop protein GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) from native virions. Journal of Virological Methods. 147:127-135.

136. Patel D., T. Opriessnig, D.A. Stein, P.G. Halbur, X.J. Meng, P.L. Iversen, and Y.-J. Zhang. 2008. Arginine-rich Cell Penetrating Peptide-conjugated Morpholino Oligomers Inhibit Porcine Reproductive and Respiratory Syndrome Virus Replication in vitro. Antiviral Research. 77:95-107.

135. Zhou E, Guo H., F. F. Huang, Z. F. Sun, X.J. Meng. 2008. Identification of two neutralization epitopes on the capsid protein of avian hepatitis E virus (avian HEV) by epitope mapping. Journal of General Virology. 89(2):500-508.

134. Meng XJ, HL Shivaprasad, and C Payne. 2007. Hepatitis E virus infections. In: M. Saif et al (eds) Disease of Poultry, 12th Edition. Blackwell Publishing Press. pp. 443-452.

133. Thomas PJ, T. Opriessnig, Juhan NM, Meng XJ, Halbur PG. 2007. Planned exposure through serum injection is not effective in preventing porcine circovirus type 2 (PCV2) infection and PCV2 associated disease (PCVAD) and lesions. Journal of Swine Health and Production. 15(6):330-338.

132. Oprissnig T, X.J. Meng, and P.G. Halbur. 2007. Porcine circovirus type 2 associated disease (PCVAD): Update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. Journal of Veterinary Diagnostic Investigation. 19(6):591-615.

131. Key KF, DiCristina J, Gillespie J, Guenette DK, and Meng XJ (2007). Direct inoculation of RNA transcripts from an infectious cDNA clone of porcine reproductive and respiratory syndrome virus (PRRSV) into the lymph nodes and tonsils of pigs initiates PRRSV infection in vivo. Archieves of Virology. March 15, 2007 ePub ahead of print.

130. Martín M., J. Segalés, F.F. Huang, D.K. Guenette, E. Mateu, N. de Deus, and X.J. Meng (2007). Association of hepatitis E virus (HEV) and postweaning multisystemic wasting syndrome (PMWS) with lesions of hepatitis in pigs. Veterinary Microbiology. Jan 3 [Epub ahead of print].

129. Guo H., E. M. Zhou, Z. F. Sun, and X.J. Meng. 2007. Egg whites from eggs of chickens infected experimentally with avian hepatitis E virus contain infectious virus, but evidence of complete vertical transmission is lacking. Journal of General Virology. 88:1532-1537.

128. Billam P, Sun ZF, and Meng XJ (2007). Analysis of the complete genomic sequence of an apparently avirulent strain of avian hepatitis E virus (avian HEV) identified major genetic differences compared with the prototype pathogenic strain of avian HEV. Journal of General Virology. 88:1538-1544

127. Huang YW, Oprissnig T, Halbur PG, and Meng XJ (2007). Initiation at the third in-frame AUG codon of open reading frame 3 of the hepatitis E virus is essential for viral infectivity in vivo. Journal of Virology. 81:3018-3026.

126. Feagins A.R., T. Opriessnig, D.K. Guenette, P.G. Halbur, and X.J. Meng (2007). Detection and characterization of infectious hepatitis E virus from commercial pig livers sold in local grocery stores in the United States. Journal of General Virology. 88:912-917.

125. Guo H, E.M. Zhou, Z.F. Sun, and X.J. Meng (2007). Protection of chickens against avian hepatitis E virus (avian HEV) infection by immunization with recombinant avian HEV capsid protein. Vaccine. 25:2892-2899.

124. Snyder. E.E., Kampanya, N., Lu, J., Nordberg, E., Rajasimha, H.K., Shukla, M., Soneja, J., Tian, Y., Xue, T., Yoo, H., Zhang, F., Dharmanolla, C., Dongre, N.V., Gillespie, J., Hamelius, J., Hance, M., Huntington, K., Jukneliene, D., Koziski, J., Mackasmiel, L., Mane, S.P., Nguyen, V., Purkayastha, A., Shallom, J., Yu, G., Gabbard, J., Hix, D., Azad, A., Baker, S., Boyle, S., Khudyakov, Y., Meng, X.J., Rupprecht, C., Vinje, J., Crasta, O.R., Czar, M.J., Dickerman, A., Eckart, J.D., Kenyon, R., Will, R., Setubal, J.C. and Sobral, B. 2007. PATRIC: The VBI PathoSystems Resource Integration Center. Nucleic Acids Research. 35:D401-6.

123. Opriessnig T, N.E. McKeown, E. Zhou, X.J. Meng, P.G. Halbur (2006). Genetic and experimental comparison of porcine circovirus type 2 (PCV2) isolates from cases with and without PCV2-associated lesions provides evidence for differences in virulence. Journal of General Virology. 87:2923-2932.

122. Opriessnig T., N.E. McKeown, K.L. Harmon, X.J. Meng, and P.G. Halbur (2006). Porcine circovirus type-2 infection decreases the efficacy of a modified live porcine reproductive and respiratory syndrome virus vaccine. Clinical and Vaccine Immunology. 13:923-929.

121. Zhang Y, Stein DA, Fan SM, Wang KY, Kroeker AD, X.J. Meng, Iversen PL, and Matson DO (2006). Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers. Veterinary Microbiology. 117:117-129.

120. Opriessnig T., M. Fenaux, P. Thomas, M. J. Hoogland, R. B. Evans, M. F. Rothschild, X.J. Meng, and P. G. Halbur (2006). Evidence of breed-dependent differences in susceptibility to porcine circovirus type 2-associated disease and lesions. Veterinary Pathology. 43:281-293.

119. Opriessnig, T., P. G. Halbur, S. Yu, E. L. Thacker, M. Fenaux, and X. J. Meng (2006). Effects of the timing of administration of Mycoplasma hyopneumnia bacterin on development of lesions associated with porcine circovirus type 2. Veterinary Record. 158:149-154.

118. Jothikumar N. J., T. Cromeans, B. Robertson, X.J. Meng, and V.R. Hill1 (2006). A broadly reactive one step real-time RT-PCR assay for rapid and sensitive detection of hepatitis E virus (HEV). Journal of Virological Methods. 131:65-71.

117. Guo H., E. M. Zhou, Z. F. Sun, XJ Meng, and P.G. Halbur. 2006. Identification of B cell epitopes in the capsid protein of avian hepatitis E virus (avian HEV) that are common to human and swine HEVs or unique to avian HEV. Journal of General Virology. 87:217-223.

116. Huang FF, Pierson FW, Toth TE, and XJ Meng (2005). Construction and characterization of infectious cDNA clones of a chicken strain of hepatitis E virus (HEV), avian HEV. Journal of General Virology. 86:2585-2593.

115. McKeown NE, T. Opriessnig, P. Thomas, D. K. Guenette, F. Elvinger, M. Fenaux, P.G. Halbur, and X.J. Meng (2005). Effects of type 2 porcine circovirus (PCV2) maternal antibodies on experimental infection of piglets with PCV2. Clinical and Diagnostic Laboratory Immunology. 12:1347-1351.

114. Kasorndorkbua C, Opriessnig T, Huang F.F., Guenette D.K., Thomas P.J., X.J. Meng, and P.G. Halbur (2005). Infectious swine hepatitis E virus is present in pig manure storage facilities on United States farms, but evidence of water contamination is lacking. Applied and Environmental Microbiology. 71:7831-7837.

113. Meng X.J., and P.G. Halbur (2005). Porcine lymphotropic herpesviruses. In: Diseases of Swine, 9th Edition. pp.550-554. Blackwell Publishing/Iowa State University Press, Ames, Iowa.

112. Meng X.J., and P.G. Halbur (2005). Swine hepatitis E virus. In: Diseases of Swine, 9th Edition. pp.537-545. Blackwell Publishing/Iowa State University Press, Ames, Iowa.

111. Meng X.J., F. Elvinger, P.G. Halbur, and C.A. Wilson (2005). Miscellaneous viral infections. In:Diseases of Swine, 9th Edition. pp.537-560. Blackwell Publishing/Iowa State University Press, Ames, Iowa.

110. Meng XJ (2005). Hepatitis E as a zoonosis. Viral Hepatitis, 3rd edition, Edited by H. Thomas, A. Zuckermann, and S. Lemon. pp611-623. Blackwell Publishing Ltd, Oxford, U.K.

109. Cooper K., F.F. Huang, L. Batista, C.D. Rayo, J.C. Bezanilla, T.E. Toth, and X. J. Meng (2005). Identification of genotype 3 hepatitis E virus (HEV) in serum and fecal samples from pigs in Thailand and Mexico, where genotype 1 or 2 HEV strains are prevalent in respective human populations. Journal of Clinical Microbiology. 43(4):1684-1688.

108. Billam P., F.F. Huang, Z.F. Sun, F.W. Pierson, R.B. Duncan, F. Elvinger, D.K. Guenette, T.E. Toth, and X. J. Meng (2005). Systematic pathogenesis and replication of avian hepatitis E virus in specific-pathogen-free adult chickens.Journal of Virology. 79(6):3429-37.

107. Meng X.J. (2005). Hepatitis E virus: Cross-species infection and zoonotic risk. Clinical Microbiology Newsletter. 26(6):43-48.

106. Huang Y.W., G. Haqshenas, C. Kasorndorkbua, P. G. Halbur, S. U. Emerson, X.J. Meng (2005). Capped RNA transcripts of full-length cDNA clones of swine hepatitis E virus are replication-competent when transfected into Huh7 cells and infectious when intrahepatically inoculated into pigs. Journal of Virology. 79:1552-1558.

105. Emerson, S.U., Anderson, D., Arankalle, A., X.J. Meng, Purdy, M., Schlauder, G.G. and Tsarev, S.A. (2004). Hepevirus. In: Virus Taxonomy, VIIIth Report of the ICTV. Fauquet C.M., M.A. Mayo, J. Maniloff, U. Desselberger, and L.A. Ball (eds), pp851-855. Elsevier/Academic Press, London.

104. Fenaux M., T. Opriessnig, P. G. Halbur, Y. Xu, B. Potts, and X.J. Meng (2004). Detection and in vitro and in vivo characterizations of porcine circoviruses from porcine-derived commercial pepsin product. Journal of General Virology. 85:3377-3382.

103. Kasorndorkbua C., D.K. Guenette, F.F. Huang, P.J. Thomas, X.J. Meng, and P.G. Halbur (2004). Routes of transmission of swine hepatitis E virus in pigs. Journal of Clinical Microbiology. 42:5047-5052.

102. Fenaux M, T. Opriessnig, P.G. Halbur, F. Elvinger, and X.J. Meng (2004). Two amino acid mutations in the capsid protein of type 2 porcine circovirus (PCV2) enhanced PCV2 replication in vitro and attenuated the virus in vivo. Journal of Virology. 78:13440-13446.

101. McKeown N.E., M. Fenaux, P.G. Halbur, X.J. Meng (2004). Molecular characterization of porcine TT virus, an orphan virus, in pigs from six different countries. Veterinary Microbiology. 104:113-117.

100. Opriessnig T., E.L. Thacker, S. Yu, M. Fenaux, X.J. Meng, P.G. Halbur (2004). Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2. Veterinary Pathology. 41(6):624-640.

99. Lekcharoensuk P, I. Morozov, P.S. Paul, N. Thangthumniyom, W. Wajjawalku, and X.J. Meng (2004). Epitope mapping of the major capsid protein of type 2 porcine circovirus (PCV2) using chimeric PCV1 and PCV2 viruses. Journal of Virology. 78:8135-8145.

98. Sun Z.F., C.T. Larsen, F. F. Huang, P. Billam, F. W. Pierson, T. E. Toth, and X.J. Meng (2004). Generation and infectivity titration of an infectious stock of avian hepatitis E virus (HEV) in chickens and cross-species infection of turkeys with avian HEV. Journal of Clinical Microbiology. 42:2658-2662.

97. Sun Z.F., and X.J. Meng (2004). Antigenic Cross-reactivity between the Nucleocapsid Protein of SARS Coronavirus and Polyclonal Antisera of Antigenic Group I Animal Coronaviruses: Implication for SARS Diagnosis. Journal of Clinical Microbiology. 42:2351-2352.

96. Fenaux M, T. Opriessnig, P.G. Halbur, F. Elvinger, and X.J. Meng (2004). A Chimeric Porcine Circovirus (PCV) with the Immunogenic Capsid Gene of the Pathogenic PCV2 Cloned Into the Genomic Backbone of the Non-Pathogenic PCV1 Induces Protective Immunity Against PCV2 Infection in Pigs. Journal of Virology. 78:6297-6303.

95. Huang FF, Z.F. Sun, S.U. Emerson, R.H. Purcell, H.L. Shivaprasad, F.W. Pierson, T.E. Toth, and X.J. Meng (2004). Determination and analyses of the complete genomic sequence of avian hepatitis E virus and attempts to experimentally infect rhesus monkeys with avian HEV. Journal of General Virology.  85:1609-1618.

94. Sun ZF, C. Larsen, A. Dunlop, F. Huang, F. Pierson, T. Toth, and X.J. Meng (2004). Genetic identification of avian hepatitis E virus (avian HEV) from healthy chicken flocks and characterization of the capsid gene of 14 avian HEV isolates from chickens with hepatitis-splenomegaly syndrome in different geographic regions of the United States. Journal of General Virology.  85:693-700.

93. Opriessnig T, M. Fenaux, J. M. Gallup, S. Yu, R. B. Evans, D. Cavanaugh, F. J. Pallares, M. R. Ackermann, E. Thacker, K. M. Lager, X.J. Meng, and P. G. Halbur (2004). Effect of porcine parvovirus vaccination on the development of PMWS in segregated early weaned pigs coinfected with type 2 porcine circovirus and porcine parvovirus. Veterinary Microbiology. 98:209-220.

92. Fenaux, M., T. Opriessnig, P.G. Halbur, X.J. Meng (2003). Immunogenicity and pathogenicity of the chimeric infectious DNA clones between pathogenic type 2 porcine circovirus (PCV2) and non-pathogenic PCV1 in weaning pigs. Journal of Virology. 77:11232-11243.

91. Key, K.F., D.K. Guenette, K.J. Yoon, P.G. Halbur, T.E. Toth, and X.J. Meng (2003). Development of a heteroduplex mobility assay to identify field isolates of porcine reproductive and respiratory syndrome virus with nucleotide sequences closely related to those of modified live-attenuated vaccines. Journal of Clinical Microbiology. 41:2433 -2439.

90. Kasorndorkbua, C., B.J. Thacker, P.G. Halbur, D.K. Guenette, R. Beitenwerf, R. L. Royer, and X.J. Meng (2003). Experimental infection of swine hepatitis E virus in pregnant gilts. Canadian Journal of Veterinary Research. 67:303-306.

89. Opriessnig T, Yu S, Gallup J.M., Evans R.B., Fenaux M, Pallares F, Thacker E.L., Brockus C.W., Ackermann M.R., Thomas P, Meng X.J., and Halbur P.G. (2003). Effect of vaccination with selective bacterins on conventional pigs infected with type 2 porcine circovirus. Veterinary Pathology. 40:521-529.

88. Sun, Z.F., F.F. Huang, P.G. Halbur, S.K. Schommer, F.W. Pierson, T.E. Toth, and X.J. Meng (2003). Use of heteroduplex mobility assays (HMA) for pre-sequence screening and identifications of variant strains of avian and swine hepatitis E viruses. Veterinary Microbiology. 96:165-176.

87. Meng, X.J. (2003). Swine hepatitis E virus: cross-species infection and risk in xenotransplantation. Current Topics in Microbiology and Immunology . 278:185-216.

86. Engle RE, Yu C, Emerson SU, Meng X.J., and Purcell RH (2002).  Hepatitis E virus (HEV) capsid antigen derived from virus of human or swine origin is equally efficient for detecting anti-HEV by enzyme immunoassay.  Journal of Clinical Microbiology. 40:4576-4580.

85. Opriessnig T., P.G. Halbur, K.J. Yoon, R.M. Pogranichniy, E.M. Vaughn, K.M. Harmon, R.Evans, K.F. Key, F.J. Pallares, P. Thomas, X.J. Meng (2002). Comparison of molecular and biological characteristics of a modified live PRRSV vaccine (RespPRRS/Repro™), the parent strain of the vaccine (ATCC VR2332), ATCC VR2385, and two recent field isolates of PRRSV. Journal of Virology. 76:11837-11844.

84. Huang FF, G.Haqshenas, D.K. Guenette, P.R. Woolcock, H.L. Shrivaprasad, C.T. Larsen, F.W. Pierson, T.E. Toth, X.J. Meng (2002).Heterogeneity and seroprevalence of the newly-identified avian hepatitis E virus from chickens in the United States. Journal of Clinical Microbiology. 40:4197-4202.

83. Halbur PG, Pallares FJ, Rathje JA, Evans R, Hagemoser WA, Paul PS, and X.J. Meng (2002). Effects of different U.S. isolates of porcine reproductive and respiratory syndrome virus (PRRSV) on blood and bone marrow parameters of experimentally infected pigs. Veterinary Record  151:344-348.

82. Huang, F.F., G.Haqshenas, D.K. Guenette, P.G. Halbur, S.Schommer, F.W. Pierson, T.E. Toth and X.J. Meng (2002).Detection by RT-PCR and genetic characterization of field isolates of swine hepatitis E virus from pigs in different geographic regions of the U.S.  Journal of Clinical Microbiology. 40:1326-1332.

81. Haqshenas G., F.F. Huang, M. Fenaux, D.K. Guenette, F.W. Pierson, H.L. Shivaprasda, T.E. Toth  and X.J. Meng(2002).  The putative capsid protein of the newly identified avian hepatitis E virus shares antigenic epitopes with that of swine and human hepatitis E viruses and the chicken big liver and spleen disease virus.  Journal of General Virology.  83:2201-2209.

80.  Fenaux, M., P.G. Halbur, G. Haqshenas,R. Royer, P. Nawagitgul,M. Gill,  T.E. Toth, and X.J. Meng (2002).  The cloned genomic DNA of the type-2 porcine circovirus (PCV-2) is infectious when injected into the liver and lymph nodes of SPF pigs: characterization of clinical course, virus distribution and pathological lesions.  Journal of Virology.  76:541-551.

79. Kasorndorkbua, C., P.G. Halbur, D.K. Guenette, T.E. Toth, X.J. Meng (2002). Use of a swine bioassay and a RT-PCR assay to assess the risk of transmission of swine hepatitis E virus in pigs.  Journal of Virological Methods.  101:71-78.

78. Wu, J.C., CM Chen, TY Chiang, WH Tsai, WJ Jeng, IJ Sheen, JY Chen,CC Lin, X.J. Meng (2002).Potential Subclinical spread of HEV among swine, swine handlers and different countries: a longitudinal study.Journal of Medical Virology.  66:488-492.

77.  Inzana, T.J., D.S. Lindsay, X.J. Meng, and K.W. Post (2002). Commercial Methods in Clinical Veterinary Microbiology.   In: Mannual of Commercial Methods in Clinical Microbiology.  American Society for Microbiology Press, Washington, DC. pp. 336-359.

76. Meng X.J., B. Wiseman, D. Guenette, R. A. Robinson, R.E. Engle, S. U. Emerson, R. H. Purcell, and T. E. Toth (2002). Prevalence of antibodies to the hepatitis E virus in veterinarians working with swine and in normal blood donors of the United States and other countries.  Journal of Clinical Microbiology. 40:117-122.

75. Emerson SU, Zhang M, Meng X.J., St. Clair M, Nguyen H, Huang Y, and Purcell RH (2001).  Recombinant hepatitis E virus genomes infectious for primates: importance of capping and discovery of a cis-reactive element. Proceedings of the National Academy of Sciences USA    98:15270-15275.

74. Haqshenas G. and X.J. Meng (2001). Determination of the nucleotide sequences of the extreme 3' and 5' ends of the swine hepatitis E virus genome.  Archives of Virology. 146:2461-2467.

73. Williams, T., Kasorndorkbua C., Halbur P.G., Guenette D., Toth T.E., X.J. Meng(2001).  Evidence for extrahepatic sites of replication of the hepatitis E virus in a swine model.   Journal of Clinical Microbiology.  39(9):3040-3046.

72.Key, K.F., Haqshenas G, Guenette D., S.L. Swenson, T.E. Toth, X.J. Meng (2001). Genetic characterization of the major envelope gene of acute porcine reproductive and respiratory syndrome virus isolates.Veterinary Microbiology. 83(3):249-263.

71.  Haqshenas, G., H.L. Shivaprasad, P. Woolcock, D. Read, X.J. Meng (2001).  Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis-spleenomegaly syndrome.Journal of General Virology.  82:2449-2462.

70.  Halbur, P.G., C. Kasorndorkbua, C. Gilbert, D. Guenette, M. B. Potters, R. H. Purcell, S. U. Emerson, T.E. Toth, X.J. Meng (2001).  Comparative pathogenesis of infections of growing pigs with hepatitis E viruses recovered from a swine and a human.  Journal of Clinical Microbiology.  39:918-923.

69. Meng, X.J. (2000).  Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development.  Veterinary Microbiology. 74:309-329.

68. Meng, X.J (2000).Novel strains of hepatitis E virus identified from humans and other animal species: Is hepatitis E a zoonosis?Journal of Hepatology  33:842-845.

67.  Fenaux, M., P.G. Halbur, M. Gill, T.E. Toth, and X.J. Meng (2000). Genetic characterization of type-2 porcine circovirus (PCV-2) from pigs with PMWS in different geographic regions of North America and development of a differential PCR-RFLP assay to detect and differentiate infections between PCV-1 and PCV-2. Journal of Clinical Microbiology   38:2494-2503.

66.Meng, X.J. (2000).  Zoonotic and xenozoonotic risks of the hepatitis E virus.   Infectious Disease Review.   2:35-41.

65.  Meng, X.J., S. Dea, R.E. Engle, R. Friendship, Y.S. Lyoo, T. Sirinarumitr, K. Urairong, D. Wang, D. Wong, D. Yoo, Y. Zhang, R.H. Purcell, and S.U. Emerson (1999).Prevalence of antibodies to the hepatitis E virus (HEV) in pigs from countries where hepatitis E is common or rare in the human population.  Journal of Medical Virology.  59:297-302.

64.  Kabrane-Lazizi, Y., X.J. Meng, R.H. Purcell, and S.U. Emerson.  Evidence that the genomic RNA of hepatitis E virus is capped (1999).Journal of Virology.73:8848-8850.

63.  Hsieh, S.-Y., X.J. Meng, Y.-H. Wu, A.W. Tam, S.-T. Liu, D.-Y. Lin, and Y.-F. Liaw (1999).  Identity of a novel swine hepatitis E virus in Taiwan forming a monophyletic group with the Taiwan isolates of human hepatitis E virus.  Journal of Clinical Microbiology.  37:3828-3834.

62.Kabrane-Lazizi, Y., J.B. Fine, J. Elm, G.E. Glass, H. Higa, A. Diwan, C.J. Gibbs Jr, X.J. Meng, S.U. Emerson, R.H. Purcell (1999).Evidence for wide-spread infection of wild rats with hepatitis E virus in the United States.  American Journal of Tropical Medicine and Hygiene.61:331-335.

61.  Meng, X.J., P.G. Halbur, M. Shapiro, S. Govindarajan, J.D. Bruna, I. K. Mushahwar, R.H. Purcell, and S.U. Emerson (1998).  Genetic and experimental evidence for cross-species infection by the swine hepatitis E virus.  Journal of Virology.   72:9714-9721.

60.Halbur, P.G., M. Rothschild, B.J. Thacker, X.J. Meng, P.S. Paul, J. D. Bruna. (1998).  Differences in susceptibility of Duroc, Hampshire, and Meishan pigs to infection with a high virulence strain (VR2385) of porcine reproductive and respiratory syndrome virus (PRRSV).  Journal of Animal Breedings and Genetics.  115:181-189.

59.  Meng, X.J., P.G. Halbur, J.S. Haynes, T.S. Tsareva, J.D. Bruna, R.D. Royer, R.H. Purcell, and S.U. Emerson (1998).  Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV.  Archives of Virology.  143:1405-1415

58.Meng, X.J., R.H. Purcell, P.G. Halbur, J.R. Lehman, D.M. Webb, T.S. Tsareva, J.S. Haynes, B.J. Thacker, and  S.U. Emerson (1997).  A novel virus in swine is closely related to the human hepatitis E virus.  Proceedings of the National Academy of Sciences USA   94:9860-9865.

57.Haynes, J.S., P.G. Halbur, T. Sirinarumitr, P. S. Paul, X.J. Meng, and E. L. Huffman (1997).  Temporal and morphologic characterization of the distribution of porcine reproductive and respiratory syndrome virus (PRRSV) by in situ hybridization in pigs infected with isolates of PRRSV that differ in virulence.Veterinary Pathology    34:39-43.

56.  Meng, X.J., P.S. Paul, P.G. Halbur, and M.A. Lum (1996).  Characterization of a high virulence U.S. isolate of porcine reproductive and respiratory syndrome virus in a continuous cell line, ATCC CRL11171.  Journal of Veterinary Diagnostic Investigation   8:374-381.

55.  Meng, X.J., P.S. Paul, I. Morozov, and P.G. Halbur (1996).  A nested set of six or seven subgenomic mRNAs is formed in cells infected with different isolates of porcine reproductive and respiratory syndrome virus.  Journal of General Virology   77:1265-1270.

54.Halbur, P.G., P.S. Paul, X.J. Meng, M.A. Lum, and J.A. Rathje (1996).  Comparative pathogenicity of nine U.S. porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a 5 week-old cesarean-derived-colostrum-deprived pig model.  Journal of Veterinary Diagnostic Investigation   8:11-20.

53.Halbur, P.G., P.S. Paul, M.L. Frey, J. Landgraf, K. Eernisse, X.J. Meng, J.J. Andrews, M.A. Lum, and J.A. Rathje (1996).  Comparison of the antigen distribution of two U.S. porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus.  Veterinary Pathology   33:159-170.

52.  Meng, X.J., P.S. Paul, P.G. Halbur, and I. Morozov (1995).  Sequence comparison of open reading frames 2 to 5 of low and high virulence U. S. isolates of porcine reproductive and respiratory syndrome viruses.  Journal of General Virology76:3181-3188.

51.Halbur, P.G., P.S. Paul, M.L. Frey, J. Landgraft, K. Eernisse, X.J. Meng, M.A. Lum, J.J. Andrews, and J.A. Rathje (1995).  Comparison of the pathogenicity of two U.S. porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus.  Veterinary Pathology   32:648-660.

50.  Meng, X.J., P.S. Paul, P.G. Halbur, and M.A. Lum (1995).  Phylogenetic analyses of the putative M (ORF 6) and N (ORF 7) genes of porcine reproductive and respiratory syndrome virus (PRRSV):  implication for the existence of two genotypes of PRRSV in the U.S.A. and Europe.  Archives of Virology  140:745-755.

49.Morozov, I., X.J. Meng, P.S. Paul (1995).Sequence analysis of open reading frames (ORF) 2 to 4 of the porcine reproductive and respiratory syndrome virus (PRRSV).  Archives of Virology140:1313-1319.

48.Halbur, P.G., L.D. Miller, P.S. Paul, X.J. Meng, E.L. Huffman, and J.J. Andrews (1995).  Immunohistochemical identification of porcine reproductive and respiratory syndrome virus (PRRSV) antigen in the heart and lymphoid system of three-week-old colostrum-deprived pigs.  Veterinary Pathology   32:200-204.

47.  Meng, X.J., P.S. Paul, and P.G. Halbur (1994).  Molecular cloning and nucleotide sequencing of the 3' terminal genomic RNA of porcine reproductive and respiratory syndrome virus.  Journal of General Virology   75:1795-1801.

46.Halbur, P.G., J.J. Andrews, E.L. Huffman, P.S. Paul, X.J. Meng, and Y. Niyo (1994).  Development of a streptavidin-biotin immunoperoxidase procedure for the detection of porcine reproductive and respiratory syndrome virus antigen in porcine lung.  Journal of Veterinary Diagnostic Investigation   6:254-257.

45.  Meng, X.J., P.S. Paul, E.M. Vaughn, and J.J. Zimmerman (1993).  Development of a radiolabeled nucleic acid probe for the detection of encephalomyocarditis virus infection in swine.  Journal of Veterinary Diagnostic Investigation   5:254-258.

44.Halbur, P.G., P.S. Paul, X.J. Meng, W. Hagemoser, M.A. Lum, and J.J. Andrews (1993).  Comparative pathogenicity of ten porcine reproductive and respiratory syndrome virus (PRRSV) isolates.  Veterinary Pathology   30:440.

43.Paul, P.S., P.G. Halbur, and X.J. Meng (1993).  Porcine reproductive and respiratory syndrome: An overview.  Journal of Clinical Veterinary Medicine (Japan)   11:19-28.