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DBSP Faculty

YongWoo Lee

YongWoo Lee, MS, PhD

Assistant Professor
Cellular and Molecular Biology
Department of Biomedical Sciences & Pathobiology
 
e-mail: ywlee@vt.edu

Education

1994-1997 Ph.D., Biological Sciences
Korea Advanced Institute of Science and Technology (KAIST)
Taejon, South Korea
1986-1988 M.S., Biochemistry
Yonsei University
Seoul, South Korea
1982-1986 B.S., Applied Biology and Chemistry
Seoul National University
Seoul, South Korea

Research Interests

  • Cellular and molecular mechanisms of human diseases
  • Oxidative and inflammatory pathways in vascular endothelial cells
  • Blood-brain barrier disruption and neurological disorder
  • Molecular signaling mechanisms of inflammatory gene expression

Professional Experience

2002-2004 Assistant Professor, Neurosurgery
University of Kentucky
2001-2001 Research Associate, Neurosurgery
University of Kentucky
1999-2001 Postdoctoral Scholar, Neurosurgery
University of Kentucky
1988-1998 Senior Investigator
Lotte Group R&D Center
Seoul, South Korea

SelectedPublications

  • Lee YW, Eum SY, Chen KC, Hennig B, Toborek M. Gene expression profile in interleukin-4-stimulated human vascular endothelial cells. Mol Med. 2004;10:1-9.
  • Lee YW, Eum SY, Nath A, Toborek M. Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells. Cardiovasc Res. 2004;63:139-148.
  • Lee YW, Hennig B, Toborek M. Redox-regulated mechanisms of interleukin-4-induced MCP-1 expression in human vascular endothelial cells. Am J Physiol Heart Circ Physiology. 2003;284:H185-H192.
  • Lee YW, Park HJ, Son KW, Hennig B, Robertson LW, Toborek M. 2,2',4,6,6'-Pentachlorobiphenyl (PCB104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB. Toxicol Appl Pharmacol. 2003;189:1-10.
  • Lee YW, Son KW, Flora G, Hennig B, Nath A, Toborek M. Methamphetamine activates DNA binding of specific redox-responsive transcription factors in mouse brain. J Neurosci Res. 2002;70:82-89.
  • Lee YW, Hennig B, Yao J, Toborek M. Methamphetamine induces AP-1 and NF-kB binding and transactivation in human brain endothelial cells. J Neurosci Res. 2001; 66: 583-591.
  • Lee YW, Kuhn H, Hennig B, Daugherty A, Toborek M. Interleukin-4 induces transcription of the 15-lipoxygenase-I gene in human endothelial cells. J Lipid Res. 2001;42:783-791.
  • Lee YW, Kuhn H, Hennig B, Neish AS, Toborek M. IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells. J Mol Cell Cardiol. 2001;33:83-94.
  • Lee YW, Hennig, B, Fiala M, Kim KS, Toborek M. Cocaine activates redox-regulated transcription factors and induces TNF-a expression in human brain endothelial cells. Brain Res. 2001;920:125-133.
  • Lee YW, Park HJ, Hennig B, Toborek M. Linoleic acid induces MCP-1 expression in human microvascular endothelial cells through an oxidant mechanism. J Nutr Biochem. 2001;12:648-654.